Missing data for a particular question or item is called item nonresponse. It occurs when a respondent fails to provide an answer to a required item. The ACS also considers invalid answers as item nonresponse. The Census Bureau uses imputation methods that either use rules to determine acceptable answers or use answers from similar housing units or people who provided the item information. One type of imputation, allocation, involves using statistical procedures, such as within-household or nearest neighbor matrices populated by donors, to impute for missing values.

People may have chosen to provide two or more races either by checking two or more race response check boxes, by providing multiple responses, or by some combination of check boxes and write-in responses. The race response categories shown on the questionnaire are collapsed into the five minimum races identified by the OMB, and the Census Bureau's "Some other race" category. For data product purposes, "Two or More Races" refers to combinations of two or more of the following race categories:

1. White
2. Black or African American
3. American Indian and Alaska Native
4. Asian
5. Native Hawaiian and Other Pacific Islander
6. Some other race

There are 57 possible combinations (see Appendix A) involving the race categories shown above. Thus, according to this approach, a response of "White" and "Asian" was tallied as two or more races, while a response of "Japanese" and "Chinese" was not because "Japanese" and "Chinese" are both Asian responses.

Given the many possible ways of displaying data on two or more races, data products will provide varying levels of detail. The most common presentation shows a single line indicating Two or more races. Some data products provide totals of all 57 possible race combinations, as well as subtotals of people reporting a specific number of races, such as people reporting two races, people reporting three races, and so on. In other presentations on race, data are shown for the total number of people who reported one of the six categories alone or in combination with one or more other race categories. For example, the category, "Asian alone or in combination with one or more other races" includes people who reported Asian alone and people who reported Asian in combination with White, Black or African American, Native Hawaiian and Other Pacific Islander, and/or Some other race. This number, therefore, represents the maximum number of people who reported as Asian in the question on race. When this data presentation is used, the individual race categories will add to more than the total population because people may be included in more than one category.